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Research Methods

The tools that keep a study fair

Methodology is the set of choices that protect results from chance and expectation.

  1. 01

    Randomization

    Using chance to decide who goes into which study group, which helps keep groups balanced.

    • Simple randomization
    • Block randomization
    • Stratified randomization
  2. 02

    Controls

    A comparison group gives researchers a reference point to see whether an approach makes a difference.

    • Placebo control
    • Active comparator
    • Usual care comparison
  3. 03

    Placebo Concepts

    A placebo looks like the real thing but has no active ingredient, helping separate real effects from expectations.

    • The placebo effect
    • When placebos are used
    • Why ethics boards review them
  4. 04

    Blinding

    Keeping volunteers, researchers, or both unaware of group assignments so expectations do not shape results.

    • Single blind
    • Double blind
    • Open label
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